Blogging the Human Genome

Another source of mutations is poor DNA splicing. When cells turn DNA into RNA, they copy the DNA by rote, skipping no letters. But with the full RNA manuscript in hand, cells narrow their eyes, lick a red pencil, and start slashing?think Gordon Lish hacking down Raymond Carver. This editing consists mostly of chopping out superfluous segments of RNA (segments called introns), then stitching the remaining, important bits (called exons) back together. As an example, raw RNA containing both usable exons (capital letters) and unusable introns (lowercase) might read, abcdefGHijklmnOpqrSTuvwxyz. Edited down, it says GHOST.

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